Bisocor 2.5mg Tablet | 1 Strip
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Bisocor 2.5mg Tablet 1 Strip

Generic: Bisoprolol Fumarate

Type: Tablet

Pack Size: 10 Pcs

Bisocor tablets are used for the treatment of:

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Note: Bisocor is not suitable for emergency management of hypertensive crises.
Use this medication as prescribed by a registered physician.

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✅ Description:

Bisoprolol Fumarate is a highly selective ß1 adrenergic receptor blocker, displaying the greatest affinity for ß1 receptors compared to other beta-blockers. It selectively inhibits ß1 receptors in the heart and vascular smooth muscle, reducing heart rate and cardiac output, which lowers arterial blood pressure. Unlike non-selective ß-blockers, Bisoprolol does not adversely affect lipid metabolism or HDL-cholesterol levels during long-term use.

Pack Image of Bisocor 2.5 mg Tablet

The pharmacokinetics of Bisoprolol allow for once-daily dosing, ensuring consistent plasma concentration levels with minimal variability.

  • Absorption & Bioavailability: Over 90% of Bisoprolol is absorbed from the gastrointestinal tract, with an absolute bioavailability of 88% due to minimal first-pass metabolism (<10%). Food does not affect its absorption.
  • Distribution: Bisoprolol is widely distributed, with a medium distribution volume of 3.5 L/kg.
  • Metabolism: It undergoes oxidative metabolism without conjugation, and the resulting polar metabolites are excreted renally. The primary metabolic pathway involves CYP3A4 (~95%), with minor involvement of CYP2D6.
  • Elimination: Bisoprolol clearance is balanced between renal excretion of the unchanged drug (~50%) and hepatic metabolism (~50%). The elimination half-life is 10-12 hours.
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✔️ Pregnancy & Lactation

Pregnancy:

  • Studies in animals suggest that Bisoprolol is not teratogenic at doses up to 375 times the maximum human dose. However, it showed fetal toxicity at higher doses.
  • Use during pregnancy only if the potential benefit outweighs the risk to the fetus.

Lactation:

  • Bisoprolol passes into animal milk in small amounts (<2%). It is unclear if it is excreted in human milk. Nursing mothers should discontinue breastfeeding if Bisoprolol use is necessary.
✔️ Dosage & Administration

Adults:
For mild to moderate hypertension, the dosage should be tailored to the individual:

  • Start with 5 mg once daily, either alone or combined with a diuretic.
  • If 5 mg is insufficient, increase to 10 mg daily, and if necessary, to 20 mg daily.
  • Allow at least two weeks between dose adjustments. Doses above 20 mg daily offer limited additional benefits.

Children:
The safety and efficacy of Bisoprolol in children have not been established.

Renal or Hepatic Impairment:

  • For patients with liver dysfunction (e.g., hepatitis or cirrhosis) or renal impairment (creatinine clearance <40 mL/min), start with 5 mg daily.
  • Titrate doses cautiously to avoid drug accumulation. Bisoprolol is not dialyzable, so replacement is unnecessary for dialysis patients.

Elderly:
Dose adjustments are generally not required unless significant renal or hepatic impairment is present.

Use this medication as prescribed by a registered physician.

✔️ Side effects may vary among individuals and include:
  • Fatigue, dizziness, headache
  • Gastrointestinal disturbances such as nausea, vomiting, diarrhea, constipation, or abdominal pain
  • Cold or numb extremities (e.g., hands and feet)
  • Muscle weakness or cramps
  • Bradycardia (slower than normal heart rate)
  • Bronchospasms cause breathing difficulties, particularly in people with asthma or COPD
✔️ Interactions
  • Other β-Blockers: Avoid combining Bisocor with other beta-blockers.
  • Catecholamine-Depleting Drugs: Medications like reserpine or guanethidine may enhance the sympathetic-blocking effect of Bisocor, requiring close monitoring.
  • Centrally Acting Antihypertensives: Caution is needed when combining Bisocor with drugs like clonidine due to the risk of rebound hypertension. If discontinuing clonidine, stop Bisocor several days before to avoid exacerbation.
  • Antiarrhythmic Agents: Use Bisocor carefully with myocardial depressants or A-V conduction inhibitors, such as certain calcium channel blockers (e.g., verapamil, diltiazem) or antiarrhythmics (e.g., disopyramide).
  • Calcium Channel Blockers: The combination of Bisocor and calcium channel blockers with negative inotropic effects may lead to bradycardia, severe hypotension, or cardiac failure in patients with impaired ventricular function.
✔️ Bisocor should not be used in patients with:
  • Cardiogenic shock
  • Overt heart failure
  • Second or third-degree A-V block
  • Right ventricular failure due to pulmonary hypertension
  • Sinus bradycardia
✔️ Precautions & Warnings
  • Use with caution in patients with renal or hepatic impairment.
  • Patients with a history of severe anaphylactic reactions may have heightened sensitivity to allergens and may not respond to usual epinephrine doses.
✔️ Storage Conditions
  • Store in a dry place, away from heat and light.
  • Keep out of reach of children.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

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